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The exponential error model or additive error model was used for assessing the inter-study variability, which is shown in formulas (dg): where 1, i and 2, i represent the variabilities of inter-study, which are added into E max or ET 50 when available and they are assumed to be distributed normally and the distribution characteristics are a mean of 0 and variance of 1, i 2 and 2, i 2 , respectively