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4 Necroptosis in CP-induced acute kidney injury (AKI) 4.1 Fundamentals of necroptosis 4.1.1 General overview of necroptosis The term programmed cell death had been commonly used to describe caspase-dependent apoptosis until caspase-independent necrosis was identified (Linkermann et al., 2012)

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Accordingly, loss of SIRT4 enhances glutamine-dependent proliferation and genomic instability, which simultaneously contribute to tumorigenesis 151

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