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The infusion rate must be controlled to prevent bad reactions

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Indeed, antioxidant supplementation exhibited a negative impact when used before induction of oxidative stress as a result of lowering physiological ROS levels because ROS plays a role as second messengers in adipogenesis, lipid metabolism, and insulin signaling [107]

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B12 is water-soluble, and excess is excreted, so the priority is steady intake rather than occasional very high doses