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The authors thank Professor Patricia Brubaker, Departments of Physiology and Medicine, Canada Research Chair in Vascular and Metabolic Biology, University of Toronto for critical reading of the manuscript

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However, if you have diagnosed male factor infertility or significantly abnormal sperm parameters, you may benefit from targeted supplementation to reach therapeutic doses

To assess the consequences of reduced (but not completely abrogated) GPX4 activity in IECs, we silenced MODE-K cells with Gpx4 small-interfering RNA ( siGpx4 )