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A randomized controlled clinical trial showed supplementation of L-carnitine tartrate (500 mg twice daily for eight weeks) reduces the body mass index, fasting plasma glucose, insulin, and homeostatic model assessment of insulin resistance, when it is administered as monotherapy or in combination with synbiotics (Fallah and Mahdavi et al

For instance, it remains to be investigated whether GLP-1RAs act solely through direct binding to GLP-1 receptors on EAT cells or indirectly modulate EAT by regulating systemic metabolic status, as well as which precise transduction mechanisms of intracellular signaling pathways mediate this process

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Expression and distribution of vasoactive intestinal polypeptide receptor VPAC2 mRNA in human airways

doi: 10.3390/antiox12020440 179 DerynckRTurleySJAkhurstRJ