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About this article Cite this article Gwyer, D., Wragg, N.M

Additional risk factors include: Chronic kidney disease : Reduced renal clearance may impair B12 excretion Liver disease : Hepatic dysfunction can disrupt B12 metabolism and storage Myeloproliferative disorders : Certain blood cancers increase B12-binding proteins Concurrent medication use : Some drugs may interact with B12 metabolism, including metformin, proton pump inhibitors, and H2 antagonists Patients with these conditions should have B12 supplementation carefully monitored by their healthcare team

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Storage / Shelf life Hermetic container, store at room temperature (1~30 C ) in a Light-resistant / 36 months from the date of manufacture Packing unit: 1mL * 5Amp

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