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Data presented are for the efficacy estimand unless otherwise noted CI confidence interval, CV cardiovascular, CVD cardiovascular disease, CVOT cardiovascular outcomes trial, HbA1c glycated hemoglobin, HR hazard ratio, MACE major adverse cardiac events, SGLT2i sodium-glucose cotransporter-2 inhibitor, T2D type 2 diabetes a MACE-3 comprised CV death, nonfatal myocardial infarction, and nonfatal stroke Table 2