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Stays in circulation longer, allowing longer intervals between injections

Zhang T., Lv Y., Lei Y., et al., Design, Synthesis and Biological Evaluation of 1Hydroxy2Phenyl4Pyridyl1HImidazole Derivatives as Xanthine Oxidase Inhibitors, European Journal of Medicinal Chemistry 146 (2018): 668677, 10.1016/j.ejmech.2018.01.060

If your body is still fatigued or sleep-deprived, caffeine can lead to a stronger crash once its effects wear off, making you feel even more tired

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