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Acknowledgements The study was supported by the British Heart Foundation Intermediate Basic Science Research Fellowship (FS/IBSRF/21/25060) to S.M., and an ERC Advanced Investigator Award (740427, BrainEnergy), Wellcome Trust Senior Investigator Award (099222/Z/12/Z), a Rosetrees Trust grant (M153-F2), and a BHF/UK-DRI Centre for Vascular Dementia Research grant to D.A