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It regulates cortisol/corticosterone release and interacts bidirectionally with sleep systemsstress disrupts sleep, and poor sleep activates stress responses

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1) without increasing the incidence of arrhythmia or hospitalization or worsening heart failure [22, 40, 47,48,49,50,51,52,53,54]

The SELECT trial established cardiovascular risk reduction in overweight adults without diabetes, while the STEP HFpEF program showed symptomatic improvement in heart failure with preserved ejection fraction [2]

Castells has received research funding and consulting fees from Blueprint Medicines and consulting fees from Cogent Biosciences