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Vitamin D3 can be taken over-the-counter, whereas Vitamin B12 is best taken as a shot or IV infusion

In rare cases, starting high-dose B12 treatments for severe anemia may cause temporary imbalances in potassium levels or an acne-like rash

These include blood concentrations of total cobalamin, holo-transcobalamin (vitamin B 12 bound to transcobalamin, one of the two carrier proteins in blood

As their use has expanded, questions about cardiovascular safety have naturally emerged, particularly given that obesity itself is a major risk factor for heart disease

Use of these compounds without medical supervision may pose serious health risks including hormonal disruption, pancreatitis, hypoglycemia, and unknown long-term effects