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Indeed, in humans, a single aminoacid mutation of the receptor that hampers its signaling is associated with obesity and insulin resistance (283)

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Dulaglutide Semaglutide Liraglutide are long-acting glucagon-like peptide-1 agonists (GLP-1 agonist an incretin) GLP-1 exerts its main effect by stimulating glucose-dependent insulin release from the pancreatic islets