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Initial symptoms begin alone or in combination, and are highly variable in duration and expression

The middle layer is composed of intestinal epithelial cells (IECs), while the inner layer is inhabited by immune cells of innate and adaptative immunity [3]

In a randomized controlled trial targeting type 2 diabetes mellitus patients with chronic kidney disease, Astragalus administration significantly reduced fasting blood glucose and HbA1c levels and improved insulin resistance (Chan et al., 2024)

It also modulates metalloproteinase (MMP) activity and their inhibitors (TIMPs), influencing not just the production of new matrix but the breakdown and remodeling of existing tissue

References: BMJ