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19,67,73,74 Newly proliferated reactive astrocytes form borders that separate damaged, inflamed, and fibrotic tissue from adjacent viable neural tissue, and during this border formation newly proliferated astrocytes become transcriptionally reprogrammed to adopt new cellular interactions with non-neural cells

It is driven by factors such as vascular endothelial growth factor (VEGF), transforming growth factor beta (TGF), EDN-1, fibroblast growth factor 2 (FGF-2) produced by mast cells, keratinocytes, and fibroblasts, stimulating endothelial cells [153, 154]

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Cells throughout the body can also produce smaller amounts to meet local needs

Now available in a tablet formulation , this product provides an alternative format for controlled research applications