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Supplements Oral supplements must be converted into NAD+ precursors Injections deliver actual NAD+ directly Many patients use injections + inhaler + topical cream as a combined protocol for maximal benefits

Reported side effects from topical application are generally mild

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Because it is prohibitively expensive to test HGF in the water maze, we instead evaluated its involvement in cognition by employing the HGF antagonist Hinge to block the actions of Dihexa