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If AST is elevated over the normal levels and far above ALT and GGT, then it typically indicates the major area of damage is outside of the liver, most commonly in the heart or kidney

[DOI] [PMC free article] [PubMed] [Google Scholar] 38.Nemeth E, Tuttle MS, Powelson J, Vaughn MB, Donovan A, Ward DM, Ganz T, Kaplan J

This structure has been proposed as a fragment derived from collagen, particularly from the alpha 2(I) chain of type I collagen

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