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In a GLP-1R knockout mouse model, LTP in the CA1 area of the hippocampus was severely impaired.142 In addition, GLP-1 RA upregulated neurotrophic tyrosine kinase receptor type 2 and mTOR genes in the hippocampus of high-fat-fed mice, which are involved in regulating synaptic plasticity and LTP.143 By modulating calcium responses to glutamate and membrane depolarization,144 and AMPA receptors,139,145 GLP-1 RA may play important roles in regulating neuronal plasticity

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