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W.et al (2018)

The terminal product of the AroAT pathway, indole-3-propionic acid (IPA), is absorbed by intestinal enterocytes and delivered to the body where it exerts numerous biological activities in humans by interacting with and activating several receptors of the nuclear receptor family including PPAR, PPAR/, PXR, and the aryl hydrocarbon receptor (AhR)

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When the needle penetrates the skin, it may inadvertently pass through one of these tiny blood vessels, causing minor bleeding

In evaluating the rationale and efficacy of newer surgical procedures, full cognizance should be taken of these developments