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Furthermore, in a phase II study, the combination of chemotherapy (albumin-bound paclitaxel and gemcitabine) along with pegvorhyaluronidase alfa (PEGPH20), an agent designed to degrade hyaluronan, has been shown to improve progression-free survival in pancreatic cancer patients, especially those with hyaluronan-high tumors [136]

Jiang, S., Zhang, X

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It also increases the secretion of gonadotropin-releasing hormone (GnRH) from part of the hypothalamus, inducing the depolarization of hypothalamic nerve cells to increase its secretory activity Figure 5 [90, 91]

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