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The authors explained that GLP-1 receptor agonists target many of the systemic risk factors of NAION

192 In the postprandial period, GLP-1 levels rise in the circulation to 4060pM from 515pM during fasting

The Gut Microbiome Connection Prebiotic fibers like inulin and psyllium work through your gut microbiome

GLUT1 is constitutively expressed on the cardiomyocyte plasma membrane and is responsible for basal glucose uptake, whereas GLUT4 is predominantly stored in intracellular vesicles and translocates to the plasma membrane in response to insulin stimulation or increased mechanical workload, thereby enhancing glucose uptake capacity (58)

Expert Opin Investig Drugs 30(2):8593 Brigelius-Floh R, Maiorino M (2013) Glutathione peroxidases