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The workflow underscores the importance of considering the additive burden of genetic variants typically classified as benignbeyond the ACMG pathogenicity frameworkfor accurate phenotypic assessment

The primary endpoint might be a reduction in 1-year heart failure hospitalization rates or improvement in left ventricular ejection fraction, with secondary endpoints including quality-of-life scores and biomarkers

See Methods for additional details about the applied fluorescent compounds

the max is 15 mg)

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