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Escalation phase (roughly weeks 520): step up about every four weeks 5 7.5 10 12.5 15 mg but only as tolerated

The mechanism of action is mediated by its binding to the GLP-1 receptor on -cells of the pancreas to stimulate insulin secretion, slow gastric emptying, and reduce postprandial glucagon secretion in a glucose-dependent fashion

But understanding potential issues helps you troubleshoot quickly if something feels off

The SURMOUNT-1 data shows 10 mg participants lost an average of 21.4 percent of body weight, around 49 pounds or 22 kilograms

6 Alternatively, some patients may be prescribed sulfonylureas or thiazolidiniones to improve insulin secretion, but both of these treatment options are associated with an elevated risk of heart failure making them unsuitable for use in patients with cardiovascular disease