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Throughout the 14 days of observation after oral administration, there were no deaths and clinical abnormal changes observed in the treated mice, which were dosed at 1500, 3000, 6000 mg of the T1 compound per kilogram of body weight

To further assess conformational dynamics, MD simulations were performed for nanobodies

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This editing scheme ensures that each target signal is treated independently, enabling the extraction of distinct edited spectra from the dataset in the different Hadamard combinations