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In mammalian cells, APE1 also has a unique REDOX function, directing the activity of different transcription factors, thereby affecting gene expression and protein production [22]

on the other hand, they may contribute to immune escape, promoting pathological protein accumulation and neuronal dysfunction

Marre M, Shaw J, Brandle M, Bebakar WM, Kamaruddin NA, Strand J, et al

The bottom line: KLOW's safety profile looks favorable based on limited evidence, but the evidence base is thin enough that anyone using it should monitor closely, start at conservative doses, and track objective biomarkers rather than relying on subjective assessment

Science 366 , 971977 (2019)