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June 17, 2025 Editor's Note: This story was updated to reflect new information about the federal approval of Wegovy to treat patients with MASH

[DOI] [PMC free article] [PubMed] [Google Scholar] 90.Cant C., Jiang L.Q., Deshmukh A.S., Mataki C., Coste A., Lagouge M., Zierath J.R., Auwerx J

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These compounds increase SIRT1 expression or activity, collectively improving hepatic lipid metabolism, insulin signaling, oxidative stress, autophagy, and inflammatory responses, highlighting their strong multi-target pharmacological potential

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