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Gadjev et al., 2008

Above roughly 50-60 mcg/day, side-effect frequency rises faster than the perceived signaling benefit

In the nucleus, NF-B binds to the promoter regions of pro-inflammatory genes, inducing the expression of cytokines such as TNF-, IL-6, IL-1, and monocyte chemotactic protein 1 (MCP-1) as well as adhesion molecules including ICAM-1, VCAM-1 [141] (Figure 4)

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