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Phase I consists of the proliferation of cytochrome P450 enzymes, to make harmful molecules less toxic, but they still accumulate and can overwhelm the body if not detoxed through phase II

Kularatne, R.N., C

Sodium butyrate, a histone deacetylase inhibitor, reverses behavioral and mitochondrial alterations in animal models of depression induced by early- or late-life stress

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This is because, as we know, silymarin has anti-inflammatory and antioxidant prosperities, making it a great defence against oxidative stress, and possibly meaning that its neuro-protective