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Compounds targeting disulfide bond forming enzyme DsbB of Gram-negative bacteria

Reviews in Endocrine & Metabolic Disorders

The oligomer was then diluted 1/50 with a solution of plasma/PBS pH 7.4 (1:1) to afford a final concentration of 5 M and incubated at 37 C (4 L of the stock solution was diluted with 196 L of plasma/PBS, pH 7.4, 1:1)

The decreased sensitivity of cancer cells to these inhibitors may be due to several reasons, including extracellular GSH binding to and inactivating the inhibitors