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In SURMOUNT 1, prediabetes reversal to normoglycemia occurred more often in patients on tirzepatide vs

Weight trajectories stabilized after 12 months, with only small variations in the distribution of weight outcomes through year two

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Notably, the STEP TEENS trial showed that semaglutide 2.4 mg, administered once weekly via subcutaneous injection, can be used in individuals aged 12 years and older, as adolescents with obesity treated with semaglutide experienced a significant reduction in BMI compared with placebo, along with improvements in several cardiometabolic risk factors [47]