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Grip-intensive movements and repetitive elbow flexion and extension under load are the primary drivers

Since the blood-brain barrier prevents many dietary antioxidants from entering the brain, it largely relies on endogenous antioxidants such as copper- and zinc-dependent superoxide dismutase (Cu, Zn SOD1)

Information for Patients: Patients with pernicious anemia should be informed that they will require monthly injections of vitamin B12 for the remainder of their lives

Patients should be referred urgently if they have neurological symptoms, if the diagnosis is unclear, or if there is inadequate clinical response to treatment