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Br.J Clin Pharmacol 2007;64(3):335-345

It is important to take into consideration that many phytoconstituents have a low bioavailability when they are consumed orally as the body considered them xenobiotics (Kara et al., 2017) and, thus, may produce a significantly different result as that demonstrated from in vitro studies

On top of disrupting pathogen membranes in over 900 strains, grapefruit juice increases concentrations of many drugs by suppressing intestinal CYP3A4, reducing first-pass metabolism

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