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The effects of meldonium on the acute ischemia/reperfusion liver injury in rats

16 However, the burden of gastrointestinal side effects and challenges with long-term adherence limited its broader applicability and underscored the need for more effective and better-tolerated therapeutic alternatives

Moreover, there is a continuous discovery of novel drugs for which placental transport and metabolism mechanisms should be determined as soon as possible

Our experience working with research-grade peptides has shown us that mechanistic plausibility and short-term safety data are necessary but not sufficient conditions for declaring a compound safe at extended durations

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