Molecular Formula: C228H388N86O64 Amino Acid Sequence: H-LTLRKEPASEIAQSIL EAYSQNGWANRRSGGK RPPPRRRQRRKRG-OH Molecular Weight: 5358.05 g/mol View the HPLC Certificate here
The effect of GLP-1R agonists liraglutide and exendin-4 was examined in vitro on LOVO, CA-77, MCF-7, MDA-MB-231, KPL-1, MB-468, 4TI, BT483, ZR751, LNCap, PC3, ALVA-41, DU145, LNCap, PANC-1, MiaPaCa-2, PANC, CT26, SKOV3, OVCAR3, OVCAR4, A2780, and ES-2 cell lines that are expressed in several cancers including colorectal, pancreatic, thyroid, breast, prostate, ovarian, and colon (Table 1)
By modulating macrophage polarization towards an M2 subtype, GLP-1RAs can inhibit inflammation occurring in the vessel lumen, an action which would alleviate the progression of atherosclerosis (Figure 2)
Missing doses or taking extended unplanned breaks resets the accumulation curve
It also seems necessary to study possible protein modifications because allulose when consumed on a regular basis and in higher doses could as a reducing sugar undergo Maillard reactions known to modify proteins and other biological entities
