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Externally introduced arginase analogs can inhibit T cells antitumor activity by reducing the arginine level in the tumor microenvironment, just as the tumor or immunosuppressive cells expressing arginase 1 can

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If it is clear that there is a fear of needles, or if good injection technique may be an issue (e.g., due to limitations with manual dexterity or lack of injection training opportunities), then oral semaglutide would seem a reasonable approach

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