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For people with cobalt allergy (which is more common among people with nickel allergy) who are also at risk of vitamin B12 deficiency, the "general advice seems to be 'take just enough but not too much,' which isn't too different from dosing advice for all vitamins and drugs" (via ACSH)

36 months: Noticeable improvement in overall density and thickness, often with visible new growth

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Specifically, advise patients to promptly seek medical attention if they develop pain or tenderness, redness, or swelling of the genitals or the area from the genitals back to the rectum, along with a fever above 100.4F or malaise [see Warnings and Precautions (5.3)]