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Sin embargo, ante ausencia de estudios formales de carcinogenicidad a 2 aos, su uso en pacientes con neoplasia activa se considera contraindicado por precaucin mecanstica

half life 1.5-3 hours excreted by the kidney (no metabolism) Side Effects: Rare : dose-related incidence of lactic acidosis GI side effects (diarrhea, nausea, vomiting, abdominal bloating, gas, reduced appetite) (~20% of patients develop dose-related GI side effects) Vitamin B12 deficiency

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The majority of the research on metabolomics investigations of bioactive natural products in the treatment mechanisms of RA does not address or clarify whether they have hazardous side effects, which is crucial and necessitates a more comprehensive evaluation including additional clinical trials

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