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Decongestants like phenylephrine (found in Sudafed PE) or pseudoephedrine (the original Sudafed) work by narrowing blood vessels to reduce swelling in the nasal passages

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In a double-blind, placebo-controlled study using a cross-over model, 30 patients who took semaglutide lost an average of 11 pounds over 12 weeks doing nothing other than taking semaglutide they did not change their diet or activity level