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Growth hormone optimization often involves 12-16 week cycles with breaks

Despite the widespread use of serotonergic medications, benzodiazepines and cognitive behavioral therapy (CBT), therapeutic outcomes remain limited with less than 50% of patients reaching full remission and nearly one-third do not respond to conventional treatments (De Vries et al., 2016)

Even though you might want to stop tretinoin altogether during the purge, you must stick with it as the purging phase is temporary, and skin texture and clarity improvements are just around the corner