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The leading hypothesis to reconcile these findings is the early worsening phenomenon, where rapid and substantial glycemic improvement temporarily exacerbates pre-existing DR

Specifically, that work involves increasing insulin production, limiting the release of glucagon (a hormone that raises blood sugar), and slowing gastric emptying (the process in which food moves from your stomach into the intestines)

We also used the standardized mean difference with heteroscedastic population variance (SMDH) to estimate the effect size of Hedges' g

Unlike FDA-approved drugs, compounded medications are not reviewed by the FDA for safety, effectiveness, or quality

The mechanism differences between these two medications may affect body composition differently