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Abstract The majority of anticancer agents have a reduced or even complete loss of a therapeutic effect within hypoxic tumors

When applied as a cream, glutathione acts only superficially, as the glutathione molecule is too large to penetrate the skin barrier in significant amounts

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However, certain conditionsincluding autoimmune disorders, specific genetic variations in glutathione-handling enzymes, or medications affecting oxidative metabolismmay warrant provider oversight before starting supplementation