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According to research supported by the National Institutes of Health (NIH), GLP-1 receptors are distributed throughout the central nervous system, including in regions deeply tied to reward, motivation, and emotional processing (specifically the nucleus accumbens and the ventral tegmental area)

Options at that point may include switching medications, adding adjunctive therapy, investigating underlying conditions like hypothyroidism or PCOS, or reassessing whether this medication class is right for you