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A study published in the Journal of the American Medical Association found that users of semaglutide, the active ingredient in Wegovy, face a threefold increased risk of stomach paralysis compared to those using oral weight loss drugs

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Sitagliptin is a nonpeptide heterocyclic compound with rapid onset and long duration of action, whereas vildagliptin and saxagliptin are both cyanopyrrolidines with slow onset and prolonged action upon binding to the DPP4 enzyme

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