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It helps neutralize reactive oxygen species and maintain redox balance across cells and tissues.*12,13

Conversely, MYC upregulation may enhance glycolytic activity in macrophages, promoting their polarization toward the M1 phenotype, thereby creating a vicious cycle of inflammation, metabolism, and cell death, exacerbating local immune imbalance and tissue destruction in RA

Interestingly, severe TBI was also associated with lower BCAA levels than was orthopedic injury [47]

10.3390/biomedicines9050468 76 HosokawaS.YoshidaO

The cysteine residue in glutathione possesses strong affinity for heavy metals through its sulfhydryl group, forming stable metal-glutathione complexes that prevent toxic metal accumulation in tissues