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However, when stem cells are exposed to higher copper levels, they progress into differentiated cells

Thus, NCOA4 is recognized as a facilitator of ferroptosis, while HERC2 (an E3 ubiquitin ligase for NCOA4 and FBXL5), VAMP8 (involved in autophagosome-lysosome fusion), and C-MYC have the potential to influence ferritin autophagy by modulating NCOA4 expression

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Functional variants such as R61C, M420del, G465R, G401S were associated with poor response to metformin and AMPK activation, potentially affecting glucose levels and insulin response in individuals according to study conducted by Shu et al